Open peer commentary on the article “Second-Order Cybernetics as a Fundamental Revolution in Science” by Stuart A. Umpleby. Upshot: The process of writing a discussion case study requires that a researcher become embedded in the domain being studied; it entails constructing a reality as it is perceived by the participants; it demands a high level of humility, since complex environments have a tendency to thwart rational reasoning processes. Unfortunately, these very characteristics lead conventional researchers to disparage case writing, even questioning (...) whether it warrants the label of “research.” The propositions of second-order cybernetics offer a glimmer of hope to those of us who continue to write cases, as they inform us that what we are doing is science, just a different flavor of science. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

Because of the growing debate concerning the nature of Soviet-type societies, a symposium-review was organized around two important recent books on the subject. The following are discussions of either one or both of the following volumes: Ferenc Feher, Agnes Heller, Gyorgy Markus, Dictatorship over Needs, St. Martin's Press (New York, 1983). Victor Zaslavsky, The Neo-Stalinist State: Class, Ethnicity and Consensus in Soviet Society, M.E. Sharpe, Inc. (New York, 1982). In social analysis, effective explanations alternate “thick description” with “thin description” Zaslavsky's (...) The Neo-Stalinist State and Feher's, Heller's and Markus’ Dictatorship over Needs, can be seen to track “actually existine socialism” down the respective paths of “thick” and “think” analysis. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

A total of 944 expressed sequence tags generated 2212 EST loci mapped to homoeologous group 1 chromosomes in hexaploid wheat. EST deletion maps and the consensus map of group 1 chromosomes were constructed to show EST distribution. EST loci were unevenly distributed among chromosomes 1A, 1B, and ID with 660, 826, and 726, respectively. The number of EST loci was greater on the long arms than on the short arms for all three chromosomes. The distribution of ESTs along chromosome arms (...) was nonrandom with EST clusters occurring in the distal regions of short arms and middle regions of long arms. Duplications of group 1 ESTs in other homoeologous groups occurred at a rate of 35.5%. Seventy-five percent of wheat chromosome 1 ESTs had significant matches with rice sequences, where large regions of conservation occurred between wheat consensus chromosome 1 and rice chromosome 5 and between the proximal portion of the long arm of wheat consensus chromosome 1 and rice chromosome 10. Only 9.5% of group 1 ESTs showed significant matches to Arabidopsis genome sequences. The results presented are useful for gene mapping and evolutionary and comparative genomics of grasses. (shrink)

To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome 6B and (...) least on 6D. The 264 ESTs that detected orthologous loci on all three homoeologs using one restriction enzyme were used to construct a consensus physical map. The physical distribution of ESTs was uneven on chromosomes with a tendency toward higher densities in the distal halves of chromosome arms. About 43% of the wheat group 6 ESTs identified rice homologs upon comparisons of genome sequences. Fifty-eight percent of these ESTs were present on rice chromosome 2 and the remaining were on other rice chromosomes. Even within the group 6 bins, rice chromosomal blocks identified by 1-6 wheat ESTs were homologous to up to 11 rice chromosomes. These rice-block contigs were used to resolve the order of wheat ESTs within each bin. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

I TACKLE THE LIMITED QUESTION WHETHER THERE IS AN APPROPRIATE PROCEDURE FOR SUPPORTING (VIOLATION) MIRACLE CLAIMS. I DON’T ASK WHETHER THAT PROCEDURE WARRANTS BELIEF IN MIRACLES. RELYING ON VARIOUS REQUIREMENTS FOR RATIONALLY ADVANCING A (VIOLATION) MIRACLE CLAIM, I URGE THAT G ROBINSON IS WRONG IN MAINTAINING THAT MIRACLE CLAIMS ARE A "MATTER OF WHIM"; RATHER THEY RELY ON A DEFINITE METHOD. FURTHER I URGE THAT M DIAMOND IS WRONG IN MAINTAINING THAT MIRACLE CLAIMS BRING BOTH SCIENTIFIC INQUIRIES TO A PREMATURE (...) END AND SCIENTIFIC AUTONOMY UNDER THREAT; RATHER MIRACLE CLAIMS PRESUPPOSE THOROUGH AND UNIMPEDED SCIENTIFIC INQUIRIES. (shrink)

Under certain circumstances the act of apologizing has moral import. It requires a commitment to truth, adherence to moral standards, and a willingness to acknowledge and regret one's own moral failures. In this paper I examine the moral import of apologizing within the U.S. legal system and as a response to historical acts of injustice. In both of these contexts apologies are expressed in a public forum, which adds an interesting dynamic to their moral significance. Within the legal system the (...) judge, representing the interests of the community, may use apologizing to directly address the harm done to victims, as an indicator of recidivism on the part of offenders, and to help create an atmosphere of respect for law in the community at large. Different moral aspects of apologizing come to the fore in the context of historical acts of injustice. Interesting philosophical questions arise, e.g. the legitimacy of moral judgments across time and culture and the very possibility of group action. And skepticism is commonly expressed about the value of such apologies: aren't they empty words that provide no real benefit to victims or the descendants of victims? Aren't they irrelevant to the future? I identify what I hope are convincing reasons to believe that historical apologies can in fact have considerable moral value and a significant impact on the future. (shrink)

Under certain circumstances the act of apologizing has moral import. It requires a commitment to truth, adherence to moral standards, and a willingness to acknowledge and regret one's own moral failures. In this paper I examine the moral import of apologizing within the U.S. legal system and as a response to historical acts of injustice. In both of these contexts apologies are expressed in a public forum, which adds an interesting dynamic to their moral significance. Within the legal system the (...) judge, representing the interests of the community, may use apologizing to directly address the harm done to victims, as an indicator of recidivism on the part of offenders, and to help create an atmosphere of respect for law in the community at large. Different moral aspects of apologizing come to the fore in the context of historical acts of injustice. Interesting philosophical questions arise, e.g. the legitimacy of moral judgments across time and culture and the very possibility of group action. And skepticism is commonly expressed about the value of such apologies: aren't they empty words that provide no real benefit to victims or the descendants of victims? Aren't they irrelevant to the future? I identify what I hope are convincing reasons to believe that historical apologies can in fact have considerable moral value and a significant impact on the future. (shrink)

Reason and quest for revelation, by P. Tillich.--On the ontological mystery, by G. Marcel.--The problem of non-objectifying thinking and speaking, by M. Heidegger.--The problem of natural theology, by J. Macquarrie.--Metaphysical rebellion, by A. Camus.--Psychoanalysis and religion by E. Fromm.--Why I am not a Christian, by B. Russell.--The quest for being, by S. Hook.--The sacred and the profane; a dialectical understanding of Christianity, by T. J. J. Altizer.--Three strata of meaning in religious discourse by C. Hartshorne.--The theological task, by J. B. (...) Cobb.--Theology and objectivity, by S. A. Ogden.--Can faith validate God-talk? by K. Nielsen.--The logic of God, by J. Wisdom.--Mapping the logic of models in science and theology, by F. Ferré.--On understanding mystery, by I. T. Ramsey.--Teilhard de Chardin; a philosophy of precession, by E. R. Baltazar.--The nature of apologetics, by H. Bouillard.--Metaphysics as horizon, by B. Lonergan.--Deciding whether to believe, by M. Novak. (shrink)

Throughout human history illness has been socially interpreted before its range of meanings could be understood and disseminated. Writers of diverse types have been as active in constructing these meanings as doctors, yet it is only recently that literary traditions have been recognized as a rich archive for these interpretations. These essays focus on the methodological hurdles encountered in retrieving these interpretations, called 'framing' by the authors. Framing and Imagining Disease in Cultural History aims to explain what has been said (...) about these interpretations and to compare their value. (shrink)

Problems of the history of philosophy, no matter what aspect of that science they deal with, are always very important. Today, when idealist philosophy seeks to give an exaggerated picture of the importance of the major spiritual values created by the peoples of the West, these problems are acquiring particular significance. In the postwar period, the number of works published abroad on the history of philosophy has increased sharply. The most popular of the older works are being revised and reissued. (...) A great number of writings on methodology have appeared. The influence of philosophy is spreading to other fields of knowledge and to their history. Specifically, historians of culture, science, technology and art are striving, influenced by the materialist concept of history, to shed the light of philosophy upon the problems that inevitably arise in these fields when their history is studied, but which cannot be resolved by the cognitive resources of the special sciences. This circumstance renders problems of the methodology of the history of philosophy particularly important and places greater responsibility upon researchers in this field. (shrink)

This is a collection of essays written by leading experts in honour of Christopher Rowe, and inspired by his groundbreaking work in the exegesis of Plato. The authors represent scholarly traditions which are sometimes very different in their approaches and interests, and so rarely brought into dialogue with each other. This volume, by contrast, aims to explore synergies between them. Key topics include: the literary unity of Plato's works; the presence and role of his contemporaries in his dialogues; the function (...) of myth ; Plato's Socratic heritage, especially as played out in his discussions of psychology; his views of truth and being. Prominent among the dialogues discussed are Euthydemus, Phaedo, Phaedrus, Republic, Theaetetus, Timaeus, Sophist and Laws. (shrink)

I. Wesen und entwicklung des humanitätsgedankens.--II. Der socialismus.--III. Der individualismus.--IV. Der utilitarianismus.--V. Der pessimismus.--VI. Der evolutionismus.--VII. Der positivismus.--VIII. Nietzsches uebermensch.--IX. Die hauptgrundsätze einer modernen humanitätsethik.